NANOSPONGE HEALING APPROACH FOR TREATMENT OF STREPTOCOCCAL GANGRENE

Objective: The envisaged research work aims to develop a nanosponge loaded gel for the treatment of Streptococcal gangrene. Methods: In present study, permeability is enhanced by targeted drug release formulation topical clindamycin phosphate nanosponges were prepared emulsion solvent diffusion method using ethyl cellulose as retardant polymer and PVA surfactant or emulsifier. Nanosponges changing ratio (1:0.05, 1:0.1, 1:0.15) process parameters optimized 32 full factorial central design. CP then incorporated into hydrogel Carbopol 934. Results Discussion: evaluated physical appearance, content, entrapment efficiency, particle size. Characterization was done SEM formulation. vitro study indicated that varied according concentration matrix forming polymer. best standardized G5 G6 further microbiological studies. Microbial studies Staphylococcus aureus strain organism activity against measuring zone inhibition. It also found be stable 2 months during its stability Conclusion: Thus, it concluded can formulated up 24 h with increased release. Therefore, are promising delivery application being more useful than conventional therapy.